Nutritional & Blood Disorders
Transcobalamin II deficiency
Serious
ICD-10: D51 · NIH NLM
हिंदी: विटामिन बी12 विकार · தமிழ்: வைட்டமின் பி12 கோளாறு · ಕನ್ನಡ: ವಿಟಮಿನ್ ಬಿ12 ಅಸ್ವಸ್ಥತೆ · తెలుగు: విటమిన్ బి12 రుగ్మత · বাংলা: ভিটামিন বি১২ ব্যাধি · मराठी: व्हिटॅमिन बी12 विकार · ગુજરાતી: વિટામિન બી12 વિકાર
About this condition
This is a rare inherited disorder where the body cannot properly transport vitamin B12 from the intestines to cells, even though the vitamin is absorbed normally. It causes severe anemia, poor growth in children, developmental delays, and nervous system problems. Lifelong treatment with high-dose B12 injections is necessary and must be started early to prevent permanent damage.
Common symptoms
fatigue
pale skin
shortness of breath
weakness
developmental delays in children
numbness in hands
poor growth
When to see a doctor: within 24 hours
This condition in Indian languages
| Hindi (हिंदी) | विटामिन बी12 विकार · ट्रांसकोबालामिन की कमी · खून की कमी · बच्चों में विकास रुकना |
| Tamil (தமிழ்) | வைட்டமின் பி12 கோளாறு · இரத்த சோகை · குழந்தைகளில் வளர்ச்சி குறைபாடு |
| Kannada (ಕನ್ನಡ) | ವಿಟಮಿನ್ ಬಿ12 ಅಸ್ವಸ್ಥತೆ · ರಕ್ತಹೀನತೆ · ಮಕ್ಕಳ ಬೆಳವಣಿಗೆ ಸಮಸ್ಯೆ |
| Telugu (తెలుగు) | విటమిన్ బి12 రుగ్మత · రక్తహీనత · పిల్లల వృద్ధి సమస్య |
| Bengali (বাংলা) | ভিটামিন বি১২ ব্যাধি · রক্তাল্পতা · শিশুদের বৃদ্ধি সমস্যা |
| Marathi (मराठी) | व्हिटॅमिन बी12 विकार · रक्ताची कमतरता · मुलांच्या वाढीत अडथळा |
| Gujarati (ગુજરાતી) | વિટામિન બી12 વિકાર · રક્તની ઉણપ · બાળકોમાં વૃદ્ધિ સમસ્યા |
Frequently asked questions
What are the symptoms of Transcobalamin II deficiency?
fatigue, pale skin, shortness of breath, weakness, developmental delays in children, numbness in hands.
When should I see a doctor?
within 24 hours
Is Transcobalamin II deficiency common in India?
This condition is seen across India.
How serious is Transcobalamin II deficiency?
Severity is classified as Serious. within 24 hours.
Related conditions
Important: This information is for general awareness only and is
not a substitute for professional medical advice. Always consult a qualified doctor.
In an emergency, call 112.
Data sourced from NIH NLM
and MOHFW India.
Full disclaimer